VDR may be a receptor that plays a role in phosphate and calcium absorption from gut. It really is found in an array of cells in the body. In particular, it is expressed in kidneys, intestines, bones, epithelial cells, and skin.
In order to understand VDR’s role in bone development, researchers considered how calcaneus density is usually correlated with VDR receptor alleles in individuals. They found that a genetic variant with the VDR was associated with smaller vitamin D levels. This getting supports the notion that the VDR gene plays a straight from the source purpose in cuboid development.
Researchers have also inspected the effect of pharmacologic dosage of calciferol derivatives on the activity of VDR. These studies revealed that the pharmacologic dose of 10-7 M of 1, 25-dihydroxyvitamin D3 decreased VDR mRNA appearance by fifty percent in HL-60 cells following 24 hours.
Research using individuals primary glioblastoma cell lines have shown that the VDR protein is present in a variety of resistant cell types, including a subset of glia. However , inside the majority of situations, the proteins seems to lack any distinct VDR-like features.
Additionally , the presence of VDR is also considered to play a role in the maintenance of nutrient balance. The VDR/RXR complicated relays the signal through hydrogen-deuterium exchange.
Functional research have suggested that the healthy proteins may have a number of domains. In particular, the ligand-binding sector, which is located among amino acids 317 and 395, may be essential for heterodimerization.