Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological plans and you can pharmacology away from curcumin
Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin is the biggest element of new red-colored dye out-of turmeric, a keen Indian spruce which is obtained from the rhizome of the warm bush Curcuma longa, and therefore is one of the Zingiberaceae relatives. Inside chapter, i discuss the pharmacological circumstances out of curcumin and discuss the fresh new molecular angles for those factors. I following review the demonstrated and you may potential scientific uses out-of curcumin. Curcumin known historically just like the a restorative agent, however, their procedure regarding step was detail by detail. The pharmacological negative effects of curcumin be seemingly the result of a beneficial synergism out-of systems away from poor biochemical affairs with several physiological purpose from inside the interrelated signaling routes. Such purpose were minerals including cyclooxygenase, lipoxygenase and you can protein kinases, and transcription things particularly NF-?B, STAT and Nrf2. Modulation of them particles has an effect on downstream affectors which make the fresh new antiinflammatory, antioxidant, chemopreventive, anticancer, and you will antimicrobial things from curcumin. These types of effects was checked-out during the medical samples of curcumin to own serious pain and you may inflammatory ailment, disease, Alzheimer disease, aerobic ailment, and you may diabetes. The latest examples used variable amounts away from curcuminwith some other frequencies and duration, to the standard end you to definitely highest dosages out of curcumin during the level of g have to receive healing effects. Read more
Curcumin: Synthesis, Emerging Role inside the Soreness Government and Health Effects
Book Part Samples of plant-derived pharmaceuticals with end up being the notice of continued and you will great lookup and you may creativity attention possess, so far, started a little scarce. Immediately after several years, the final twenty years were characterized by a 100-fold rise in how many medical posts composed a year you to try of value to the usage of curcumin into the biomedicine. Read more
Build, synthesis and you will biological facts from curcumin prodrugs
Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many possible pharmacological consequences and might has actually therapeutic programs in several situation states, as the chatted about in detail in the earlier chapter. Although not, the potential clinical efficacy away from curcumin is bound from the the physicochemical services of worst water solubility and you will instability, and therefore end up in reduced bioavailability. Prodrugs away from curcumin offer a means to improvement of biopharmaceutical and pharmacokinetic features, and could make it exploitation of your pharmacological negative effects of curcumin. Inside section, we basic opinion the brand new physicochemical and you will pharmacokinetics away from curcumin. We then describe the design of curcumin prodrugs that have increased liquids solubility and you can improved toxins balance that is certainly converted to totally free curcumin through to bioactivation within the vivo. We focus on previous victory in this region, that have a focus on the design, synthesis and evaluation out-of prodrugs centered on promoieties also proteins, fatty acids, nucleic acids, dicarboxylic acids, and you Kuubalainen vaimo will polymeric information such as hyaluronic acidic and you may polyethylene glycol. It section has the reason for optimization of physicochemical and biopharmaceutical properties and biological issues out-of curcumin prodrugs, to the goal having fun with of these curcumin types when you look at the systematic applications. Find out more